San Ramon was historically settled by a mixture of Sumo and Miskito peoples from Nicaragua's Atlantic coast, as well as by Chontales Indians, who are a branch stemming from the ancient Mayans.

Other tourist attractions that are nearby and directly affect the town's revenue are the eco-resort "Esperanza Verde" and "La Selva Negra".

Seattle-based non-profit, Corner of Love, leads more than twenty medical-dental-optical brigades per year to serve in San Ramon and sixty outer-lying villages.

San Ramon's local tourism office is supported by the Interamerican Foundation and is currently working on a web page, and USAID and Peace Corps have frequently been present there.

Additionally, San Ramon is the location of the Associacion Catalana where Spaniards consult and assist the locals in coffee production, adult education, building initiatives with wood and bamboo, and teaching scholarships.