Sanatorium is an unincorporated community in Simpson County, Mississippi, United States, northwest of Magee.

In 1976, the old Sanatorium facilities were transferred to the Mississippi Department of Mental Health and renamed Boswell Regional Center, which is now an Intermediate Care Facility for Persons with Mental Retardation and other developmental disabilities (ICF-MR).

Its central building, Dexter Hall, received a Heritage Award for Restoration in 2014.

The Scaife (San) Hotel on Highway 149 which was converted into a halfway house in the 1990s.

In the 1990s, the Sanatorium postal address was abolished, and the local post office on the grounds of Boswell Regional Center was demolished.