Sand Creek is a stream in Henry County in the U.S. state of Missouri.
The stream headwaters are just east of Missouri Route 13 about two miles south of Shawnee Mound (at 38°31′05″N 93°45′39″W / 38.51806°N 93.76083°W / 38.51806; -93.76083) and the stream flows southeast to cross Missouri Route 52 just west of Calhoun.
The stream is impounded as a small lake west of Calhoun.
From there the stream flows south then east to its confluence with Tebo Creek (at 38°25′48″N 93°36′58″W / 38.43000°N 93.61611°W / 38.43000; -93.61611).
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