In October 2014 the 3D animated film The Book of Life was released, and Sandra designed all the female characters[5] with reality flaws and personal touches to add authenticity.

Symbolism and heritage are an essential part of her character development, evidenced in the use of traditional Mexican folkloric designs and other cultural references.

[6] In 2018, Equihua creatively consulted, voiced and created character designs for Jorge R. Gutierrez's Son of Jaguar, a VR short for Google Spotlight Stories.

In 2021, Equihua creatively consulted, voiced and created character designs for Jorge R. Gutierrez's event series Maya and the Three at Netflix Animation.

Sandra Equihua won an Annie and Emmy Award for her character designs on El Tigre: The Adventures of Manny Rivera.