Sandusky was the name of a steam railroad locomotive, a 4-2-0, built in the United States.

Sandusky was the first locomotive built by Rogers, Ketchum & Grosvenor; it was completed in 1837.

While some references cite Sandusky as the first locomotive built in the United States, the Best Friend of Charleston is more widely accepted as the first; the Best Friend of Charleston was built in 1831.

The Sandusky, however, was the first locomotive to feature counterweights in its driving wheels to offset the force of the piston stroke and the combined weight of the axle, wheels and piston rod against the railroad track.

Sandusky also featured the first use of hollow oval-shaped spokes in its driving wheels.