The Sangro is a river in eastern central Italy, known in ancient times as Sagrus from the Greek Sagros or Isagros, Ισαγρος.

It rises in the middle of Abruzzo National Park near Pescasseroli in the Apennine Mountains.

During World War II, the mouth of the Sangro was part of the series of German military fortifications known as the Gustav Line.

This crossing was the beginning of the Allied offensive on the Winter Line defences east of the Apennines, which petered out in mid-December, having failed to secure vital cities such as Orsogna.

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