Sant'Agata di Militello (Sicilian: Sant'Àita di Militeddu) is a comune (municipality) in the Metropolitan City of Messina in Sicily, Italy, located about 120 kilometres (75 mi) east of Palermo and about 80 kilometres (50 mi) west of Messina.

Sant'Agata di Militello borders the following municipalities: Acquedolci, Militello Rosmarino, San Fratello, Torrenova.

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