Sant'Angelo di Brolo (Sicilian: Sant'Àncilu di Brolu) is a comune (municipality) in the Metropolitan City of Messina in the Italian region Sicily, located about 130 kilometres (81 mi) east of Palermo and about 60 kilometres (37 mi) west of Messina.

Sant'Angelo di Brolo borders the following municipalities: Ficarra, Raccuja, San Piero Patti, Piraino, Brolo, Gioiosa Marea, Librizzi, Montagnareale, Sinagra.

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