It is situated 7 kilometres (4 mi) north of Randazzo in the Nebrodi Mountains Range.

The comune borders the following municipalities: Floresta, Montalbano Elicona, Randazzo, and Roccella Valdemone.

Santa Domenica Vittoria is named after a Calabrian saint, who was a victim of the Roman persecution of Christians under Diocletian.

The actual feast day is 17 January, but given the cold winters that are usually accompanied by heavy snow and below freezing conditions, it is celebrated on the first Sunday of September.

On the day of the feast many of the men of the town dress in white and carry a statue of St Anthony in a procession through every street of town and the townspeople traditionally pin money to the statue as it passes by their balconies.