The territory of the municipality of Santa Lucia del Mela, one of the largest in the province (less than 83 km ²), has a rich variety of landscapes.

Greek ruins (on the left bank of the river Floripotamo remains of the temple of Diana Facellina were found) and 2nd century BC Roman tombs attest the presence of Greek-Roman settlements.

After his conquest of Sicily, the Norman Count Roger I, to fulfill a vow, built a church (1094) adjacent to the castle and dedicated to Saint Lucy, to whom he was devoted.

In addition, the Prelate of Santa Lucia was awarded the honor of serving as Major chaplain of the kingdom and the town was entitled to 11 seats in Parliament.

He emitted a proclamation calling on the population of the plain, which was subject to recurrent raids by pirates, to resettle inside the town walls.

The town once sheltered a major Giudecca, a large Jewish community, in the current area of Candlemas; however, in 1492, Jews in Sicily, then under Aragonese rule were subject to Expulsion.