Sant'Erasmo is a Roman Catholic church located in Castel Goffredo, region of Lombardy, Italy.

[1] From the statutes of the Congregation of Santa Maria della Misericordia it appears that before 1288 there was a church in Castel Goffredo dedicated to Erasmus of Formia, which presumably stood within the perimeter of Castelvecchio (Castellum vetus), demolished in 1516 to make room for the garden by Prince Aloisio Gonzaga.

During the marquisate of Aloisio Gonzaga, the temple was embellished and enlarged with the addition of the two side chapels.

In his will he left the sum of one hundred crowns to be employed in the work on the church.

Cardinal Carlo Borromeo, during his visit in 1540, gave instructions for changes to be made inside and the work to be completed.