Sant'Ippolito is a comune (municipality) in the Province of Pesaro e Urbino in the Italian region Marche, located about 50 kilometres (31 mi) west of Ancona and about 25 kilometres (16 mi) south of Pesaro.

Sant'Ippolito borders the following municipalities: Fossombrone, Fratte Rosa, Montefelcino, Orciano di Pesaro, Serrungarina, Terre Roveresche.

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