[citation needed] The center was erected on the site of a former Atchison, Topeka and Santa Fe Railway combination depot that had been constructed in 1939 and closed in 1982.

[8] Santa Ana Regional Transportation Center will be the eastern terminus of the OC Streetcar, a 4.15-mile (6.68 km) streetcar line through Downtown Santa Ana, a major regional employment area, to a new transit center and Park and Ride in Garden Grove at Harbor Boulevard and Westminster Avenue (both major bus corridors).

[7] Santa Ana Regional Transportation Center is served by 20 Amtrak Pacific Surfliner trains (ten in each direction) evenly spaced throughout the day.

[9] Santa Ana Regional Transportation Center is served by 26 Metrolink Orange County Line trains (13 in each direction) each weekday, evenly spaced throughout the day.

Weekend service consists of 4 trains (2 in each direction) on both Saturday and Sunday, heading towards Orange County in the morning and towards the Inland Empire in the evening.