Santa Cruz is a census-designated place (CDP) in Starr County, Texas, United States.

It was formed for the 2010 census with a population of 54.

[1] There is a former CDP of the same name (Santa Cruz CDP) that was split prior to the 2010 census into the El Chaparral and Santa Rosa CDPs.

[1] Santa Cruz is located at 26°21′13″N 98°46′3″W / 26.35361°N 98.76750°W / 26.35361; -98.76750 (26.353689, -98.767615).

[2]