Originally, the region was named "Santa Cruz Belén de los Indios Choles" (Bethlehem Holy Cross of the Chole Indians), and it was settled in 1603 (according to the friar Joseph H. Sotomayor), which makes it one of the oldest Spanish towns in Guatemala.

Verapaz Mayor, Joseph Calvo de Lara, founded the town in Urram valley, next to Rabinal mountain on a location that the Indians called "San Clemente and San Diego", where there was a cross, and therefore it was named "Santa Cruz".

[4] Santa Cruz El Chol annual festival takes places on 8 December in honor of the municipality saint patron: Holy Virgin of the Immaculate Conception.

The festival is famous for its commercial activities, sports events, cultural, social and religious festivities and the traditional processions and "Romería", activity in which people rides horses for three days from the Eastern side of Guatemala to present the town's Catholic Church with gifts, prayers and special songs.

El Chol is located 52 km East of Salamá, Baja Verapaz Department capital city.