It is 121 kilometers from the state capital, Goiânia and is connected by BR-352 / Bela Vista de Goiás / Cristianópolis / GO-020.

The municipality is bathed by the Rio dos Bois, Rio do Peixe, córregos Manoel Duarte, Muquém, Buriti, Pedra de Amolar, Brumadinho, Caiapó, Pirapitinga, Fundo, Mato Virgem, Água Suja, São Benedito, Córrego da Chuva, Sapé, Dantas, and by the Ribeirão Brumado.

The economy is based on agriculture, cattle raising, services, public administration, and small transformation industries.

Agricultural data 2006 Human Development Index Unlike many of the municipalities in Goiás, Santa Cruz has its origins in the 18th century, when mule drivers in 1721 on their way to the mines of Cuiabá discovered gold in the region.

With attractive landscapes around the city, Santa Cruz has rivers and waterfalls that promise future touristic development.