It is the conventual church of the adjacent General Curia of the Clerks Regular, Ministers to the Sick (Camillians), the world headquarters of the order.

In 1586 Saint Camillus de Lellis was given the church as the seat of the Clerks Regular, Ministers to the Sick (Italian: Ministri degli Infirmi).

The historian Alessandra Marino believes that it is to Dos Santos, rather than Giuseppe Sardi, that the design for the highly unusual façade decoration should be attributed.

[3] To the left of the church is the monastery, constructed circa 1678, by Paolo Amato from Palermo and completed by Carlo Francesco Bizzacheri in the early 1680s.

[citation needed] The sacristy is a unique example of the Roman "Barocchetto" style made between 1738 and 1741, with wooden wardrobes and presses painted to resemble marble.

This picture is said to have been painted by the celebrated Dominican, Fra Angelico and before it Pope Pius V is reportedly to have prayed for the victory of the Christian fleet during the Battle of Lepanto (1571).