Santa Maria della Quercia (Our Lady of the Oak Tree) is a Roman Catholic church located on the piazza of the same name, one block southeast of the Palazzo Farnese in the Rione (district) of Regola of central Rome, Italy.

A prior church at the site was named San Niccolò de Curte or de Ferro, with the former referring to the ancient Roman noble family of the Orsini, who had their palace nearby;[1] and the latter name likely referring to the Capodiferro family who once owned the nearby Palazzo Spada in the contiguous Piazza Capo di Ferro.

In addition the quercia or oak was the emblem on the heraldic shield of the House of Della Rovere, to which Pope Julius belonged.

Pope Benedict XIII in the early 18th century entrusted the reconstruction to Filippo Raguzzini,[3] later completed by Domenico Gregorini by 1731.

Above the main altar is a replica of the icon of the Madonna della Quercia di Viterbo.