Santa Maria Materdomini is a Roman Catholic church located near piazzetta Fabrizio Pignatelli, in Naples, Italy The church was founded in 1573–75 by the Fabrizio Pignatelli, brother of the second duke of Monteleone, knight of the Priory of Jerusalem (Gerosolimitani or Knights Hospitaller), and former Bailiff of Santa Eufemia in Calabria.
On the entry door was a Madonna con Bambino by Francesco Laurana (15th century), now found on the main altar.
The interior contains the marble and bronze Funereal Monument of Fabrizio Pignatelli, commissioned in 1590 from Michelangelo Naccherino and completed in 1609.
To the left of the monument is a painting depicting the Virgin with Pilgrims and Charity (1721) by Leonardo Olivieri, a pupil of Solimena[2] On the right of the tomb is a painting by Nicola Malinconico depicting Virgin with Saints Gennaro and Francesco di Paola.
The church also has a 19th-century Funereal Monument of Maria Luisa Colonna di Stigliano, by Francesco Liberti.