Santa Maria Nuova is a comune (municipality) in the Province of Ancona in the Italian region Marche, located about 20 kilometres (12 mi) southwest of Ancona.

Santa Maria Nuova borders the following municipalities: Filottrano, Jesi, Osimo, Polverigi.

Among the churches in the city is the 18th-century church of San Giuseppe and the church of Sant'Antonio di Padova.

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