Santa Maria delle Grazie is a church in Arezzo, Tuscany, central Italy.
It is located on the site of an ancient sanctuary with a spring that, in the Etruscan-Roman era, it was consecrated to Apollo.
The altar portrays, in the tympanum, a Madonna with Child between two Angels; in the niches are the saints Laurentinus, Pergentinus, Donatus and Bernardino, while the paliotto has a Pietà.
The church itself was built from 1435 to 1444, a late Gothic edifice designed by Domenico del Fattore, with a single nave with cross-vaults and a short apse.
It houses a fresco (c. 1477–1481) with Pope Sixtus IV Enthroned between cardinals Gonzaga and Piccolomini.