Santiago Tlazoyaltepec is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 93.13 km2.

It is part of the Etla District in the Valles Centrales region.

As of 2005, the municipality had a total population of 4,357.

[1] This article about a location in the Mexican state of Oaxaca is a stub.