Santo Domingo Tepuxtepec is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of km².

It is part of the Sierra Mixe district within the Sierra Norte de Oaxaca Region.

[1] As of 2015, the municipality had a total population of 4,815 inhabitants.

[2][3] This article about a location in the Mexican state of Oaxaca is a stub.