Santos Reyes Tepejillo is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of km² and is part of the Juxtlahuaca District of the Mixteca Region.

[1] Aparicio Reyes, municipal president, became the 14th municipal president of Oaxaca to die of COVID-19 on January 31, 2021.

[2] As of February 18, there were seven confirmed cases and one death in the municipality due to the pandemic.

[3] This article about a location in the Mexican state of Oaxaca is a stub.