[1][2][3] Ziff has appeared as the face of advertising campaigns for companies including Tommy Hilfiger, Kenzo, Stella McCartney, and Kenneth Cole.

She has walked in runway fashion shows for brands such as Prada, Chanel, Christian Dior, Calvin Klein, Marc Jacobs, Dolce & Gabbana, Dries Van Noten, Balenciaga, Chloé and Alexander McQueen.

[9] In 2014, Ziff released the preview of "Tangled Thread," a documentary about Bangladesh's garment industry and women organizing for better working conditions across the supply chain.

At the United Nations, Ziff introduced the organization's global flagship report, "A Life Free From Hunger – Tackling Childhood Malnutrition.

[20] In April 2023, Ziff sued Weinstein, Miramax, Disney and others alleging that she was raped by Fabrizio Lombardo who tricked her while she was working as a model for his company in 2001.