Sarcophagine (Sar) is a bicyclic cage-like metal chelator molecule[1] derived from cyclam.

Chemical formula of sarcophagine is 3,6,10,13,16,19-hexaazabicyclo(6,6,6)icosane[2] and additional functional groups are often linked to this structure, such as in DiAmSar (1,8-diamino-Sar).

This and many related hexadentate clathrochelates are prepared by template reactions.

[3] Sarcophagine derivatives are used, for example, as ligands in radiopharmaceuticals that require incorporating a radioactive metal cation into an organic and/or biological structure, such as an antibody.

[4]