The original chapel was built in 1585 with funds provided by the Knight Fra Martin Sarria Navarra.

[1] Following the devastation that the plague of 1675–76 brought on the country, Grand Master Nicolas Cotoner built in its place another church dedicated to the Immaculate Conception as a sign of thanksgiving.

[2] The church was designed by prominent painter Mattia Preti.

[3] The most precious possession of this church are the seven large canvases that surround the interior, painted by Mattia Preti.

The altarpiece, also by Preti, depicts the Immaculate Conception with angels sheltering their swords after defeating the plague of 1675–76.