Chambers, Jake Cherry, Tim Colon, Jack Conley, Felicia Day, Mos Def, Mary Jo Deschanel, Marika Dominczyk, Taylor Dooley, Treshelle Edmond, Susan Egan, Sherilyn Fenn, Erika Flores, John Forest, Nathan Gamble, Angela Gots, Judy Greer, Brad Grunberg, Wood Harris, Christine Healy, Martin Henderson, Ashton Holmes, Željko Ivanek, Evan Jones, Elaine Kagan, Eric Kaldor, John Kapelos, Jay Karnes, Dominic Scott Kay, Sarah Knowlton, Alix Korey, Joanna Koulis, Ryan Lane, Meat Loaf, Todd Louiso, Alexandra Lydon, Phyllis Lyons, Meaghan Martin, Lindsey McKeon, Breckin Meyer, Devon Michaels, Christopher Moynihan, Becky O'Donohue, Scott Paulin, Evan Peters, Drew Powell, Nick Puga, David Purdham, Samantha Quan, Ben Reed, Carl Reiner, Emily Rios, Tim Rock, Jamie Rose, Alex Schemmer, Judith Scott, Samantha Shelton, Kyle Red Silverstein, Jimmi Simpson, Alex Sol, Maria Thayer, Jake Thomas, Sarah Thompson, Lucas Till, Jamie Tisdale, Bitsie Tulloch, Natasha Gregson Wagner, Christine Woods, Salvator Xuereb, Liza Colón-Zayas and Vanessa Zima.

A painter's (Breckin Meyer) undiagnosed illness begins to affect his work, but he is unable to see his art is suddenly grotesque.

Final diagnosis: Food Bolus Bezoar complicated by massive experimental pharmaceutical drug intake House is coerced into going to his father's funeral despite his protests.

The team take on the case of a middle-aged man (Salvator Xuereb) who has been experiencing recurring blackouts, time lapses and sleepwalking.

Meanwhile, Cameron and Chase attempt to work through issues in their relationship, and House deals with an annoying itch he cannot seem to scratch, with Wilson making his own analogies about the problem.

But when the unexplained illness brings the child (Kyle Red Silverstein) to the brink of death, Foreman is left questioning his ability to work free from House's custody.

A man (Željko Ivanek) takes over Cuddy's office and holds House, Thirteen, and several patients hostage, demanding a diagnosis.

At Cameron's urging, the team takes the case of a suicidal man (Martin Henderson) who suffers from excruciating chronic pain—pain that mirrors House's.

Meanwhile, Cuddy discovers that caring for her new foster baby leaves her little time to run the hospital; and Foreman and Thirteen continue to explore their complicated relationship as they work together on their Huntington's disease drug trial.

Cuddy decides to spend more time at home to take care of her new foster baby and gives Cameron the responsibility of overseeing House.

Meanwhile, Thirteen begins to suffer serious and life-threatening reactions to her experimental Huntington's disease clinical drug trial, and Cuddy retaliates against House and gives him a taste of his own medicine.

When a priest (Jimmi Simpson) who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER.

However, just as they are about to dismiss his case, the patient's condition takes a drastic turn for the worse, and House grapples with his past and his own personal beliefs.

House and the team take on the case of Nick Greenwald (Jay Karnes), a book editor who loses his inhibitions and starts insulting co-workers at a dinner party one night before falling ill.

The team realizes Nick has frontal lobe disinhibition, which has caused him to lose his filter and vocalize all of his innermost thoughts, resulting in extremely insulting outbursts.

As Nick's free speech leads to some amusing and insightful comments regarding the team, he must deal with the consequences of being unable to lie to his wife and everyone else important in his life.

Nursing-home worker Morgan (Judy Greer) fakes illness to get House's attention after the home's pet cat, Debbie, sleeps next to her.

House must solve this daunting puzzle while going to desperate measures to cure his hallucination; he continues to suffer from a severe lack of sleep and is still haunted by Amber.

House and the team are intrigued by Scott (Ashton Holmes), a man who has undergone a corpus callosotomy procedure to treat epilepsy.

Due to this, both sides of his brain are at war for dominance over the body resulting in him having Alien Hand Syndrome where he can't control his left arm.