[3] The series follows the survivors of the damaged interstellar cargo ship Demeter 227 who are stranded on Vesta, an alien planet bustling with flora and fauna but filled with dangers.

Initially the survivors are separated into three groups: Azi and her robot companion Levi, Sam and Ursula, and the isolated Kamen, who travels with a telepathic creature named Hollow.

The website's critics consensus reads, "Disturbing and wondrous, Scavengers Reign presents a vividly realized world that beckons exploration by its marooned characters and television viewers alike.

"[10] James Poniewozik of The New York Times called it "a lush, magnificent, hypnotic story of human survival in a place that feels, in a way that sci-fi planets only occasionally manage, truly otherworldly.

"[11] Andrew Webster of The Verge deemed it to be "equal parts beautiful and brutal, and it might be the most original piece of science fiction of the year", and compared the art style to Jean “Moebius” Giraud.