The live-action cast features Nick Palatas as Shaggy, Robbie Amell as Fred, Hayley Kiyoko as Velma, and Kate Melton as Daphne.

Scooby-Doo was created using computer-generated imagery and his voice is provided by Frank Welker, who was a cast member of the original animated series.

Because of the fight on the bus and the damage to Grimes' car, Shaggy is sent to the library for detention, along with three others: Fred Jones, the quarterback of the football team; Velma Dinkley, a science nerd; and Daphne Blake, a wealthy drama club student.

The gang try to clear their names by investigating the ghosts at it, but Shaggy and Scooby-Doo end up being locked in the cafeteria freezers.

The Specter, keeping Scooby and Grimes as prisoners, forces the gang to search underground for the time capsule.

Determined to obtain the misprint, Deedle used the spell book to summon the ghosts to have the school evacuated so he can accomplish his goal.

After Deedle is arrested for his crimes, the group is re-instated to Coolsville High and publicly congratulated by Grimes, who becomes the new principal.

Just as they begin digging, Shaggy accidentally throws his shovel, which lands on Grimes' car, once again damaging its windshield.

The group decide to stay together and solve mysteries, and they head off to "investigate some strange goings-on at the Coolsville museum", a reference to the first episode of Scooby-Doo Where Are You!

Filming took place in Vancouver, British Columbia, Canada, including Templeton Secondary School from August 4, 2008.