Industry trade publication Pollstar has previously ranked Enterprise Center among the top ten arenas worldwide in tickets sold to non-team events, but the facility has since fallen into the upper sixties, as of 2017.

Signs for the nearby MetroLink stop have been changed to read "Civic Center", since the building has been renamed four times in its history.

In June 2009, the St. Louis Board of Aldermen voted 25–1 to subsidize the renovation and reopening of the Opera House under the direction of its new owners, Sports Capital Partners (who also own the Blues).

For Blues games, Tom Calhoun serves as public address announcer and Jeremy Boyer is the arena organist.

Previous anthem singer Charles Glenn retired in 2018 due to health concerns and a relocation to San Diego, but he has returned to St. Louis to sing on multiple occasions including the 2019 Stanley Cup run.

The largest crowd to attend an event at the arena was 22,612, which happened twice during the 2007 Missouri Valley Conference men's basketball tournament.

[15] A three-phase renovation of the arena began in 2017 and was completed in 2019, with all building works being done in the hockey offseason to minimize schedule disruption.

The first phase was largely composed of engineering upgrades (new lighting, sound, HVAC, and ice plant), improved IT infrastructure including free Wi-Fi for patrons, and rebuilt dressing rooms, as well as a new scoreboard and replacement of some lower-tier seating on the west end (where the Blues shoot twice) with "theater boxes".

Phase two saw the replacement of all upper-tier seats, along with "theater boxes" being added to the east end, and a rebuilt lower-tier concourse with new club areas for premium ticketholders as well as a beer garden opening onto 14th Street.

[16] In September 2006, Scottrade founder Rodger O. Riney and chief marketing officer Chris Moloney announced a partnership with the St. Louis Blues hockey club and arena.

On average, the facility sees about 175 total events per year, drawing nearly two million guests annually to downtown St. Louis.

The building is operated by SLB Acquisition Holdings LLC, owner of the St. Louis Blues, under its chairman, Tom Stillman.

At that same event, the first Hell In A Cell match took place between Shawn Michaels and The Undertaker, which received a five-star rating from the Wrestling Observer Newsletter.