Mostly sailors and workers, they initially met on a ground near the church of San Giovanni di Malta.
In that period the corporation bought the former hospital of St. Catherine in the area, and restored as its Scuola, under design by Giovanni De Zan with a façade inspired by Jacopo Sansovino.
From 1502 to 1507 the painter Vittore Carpaccio was commissioned seven panels with the Stories of the Patron Saints of the Scuola, which are still in the building.
Externally, over the entrance is a relief with St. George Killing the Dragon (1552), by Pietro di Salò and, above it, a "Virgin Enthroned with Saints" (mid-14th century) by a Venetian sculptor.
At the altar is a Patron Saint of the Scuola with, at its sides, two gilt panels of St. Jerome and St. Tryphon (15th century) Oltramarini