[1] In 1954, Penfield and Jasper evoked somatosensory sensations in human patients during neurosurgery by electrically stimulating the ceiling of the lateral sulcus, which lies adjacent to S1, and their findings were confirmed in 1979 by Woolsey et al. using evoked potentials and electrical stimulation.
[4][5] Functional neuroimaging studies have found S2 activation in response to light touch, pain, visceral sensation, and tactile attention.
[6] In monkeys, apes and hominids, including humans, region S2 is divided into several "areas".
In humans, the secondary somatosensory cortex includes parts of Brodmann area (BA) 40 and 43.
Functional neuroimaging in humans has revealed that in areas PV and S2 the face is represented near the entrance to the lateral sulcus, and the hands and feet deeper in the fissure.