Sega Genesis Collection (Sega Mega Drive Collection in PAL regions) is a compilation of video games developed by Digital Eclipse and published by Sega for PlayStation 2 and PlayStation Portable.

The collection includes twenty-eight Sega Genesis games from a variety of genres, as well as unlockable classic Sega arcade games, with different sets of arcade games for the PlayStation 2 and PlayStation Portable versions.

A sequel was released in 2009 called Sonic's Ultimate Genesis Collection for PlayStation 3 and Xbox 360.

This collection also features more than thirty-five minutes of unlockable interviews from Sega of Japan, a "museum" with facts about the games, strategy tips and box art for each game, as well as a "Sega Cheat Sheet" that consists of cheat codes for most games, and a set of unlockable arcade games, (some of which are from the early Sega/Gremlin era).

The collection also contains unlockable trailers for Phantasy Star Universe and Virtua Fighter 5.