It is an official entry to the 2016 Metro Manila Film Festival, where it won 9 categories, including "Best Director" award for Erik Matti.

[5] In 1947, Padre Ricardo arrives at a marketplace to investigate people whose ailments were miraculously healed by a child named Anghela Santa Ana, who is assisted by a mysterious nun, Sister Cecilia.

Sandoval tells him about an old custom where temporary deacons and aspiring priests are sequestered at the very end of their training, as it is believed in the last seven days they are most vulnerable to demonic influence.

During the course of their stay, the deacons are plagued by recurring nightmares based on their sins: Marco's gluttony caused his siblings to die from starvation in the recently-ended Second World War; Fabián's entry into the priesthood was his escape from a physically abusive mother; and Miguel is taunted by his dead ex-lover, Erina, in a grotesque form of Our Lady of Sorrows.

As Anghela convinces him that he was innocent of his sins, Sandoval departs the next morning, thanking the girl and leaving the deacons under her charge.

As the deacons finish their training, Anghela convinces them to redeem themselves from their sins by feeding their vices, sometimes using Sister Cecilia as a pawn for her schemes.

The film ends with Fabián, Carlo, and Marco being ordained to the priesthood by a new bishop, who is unaware they were consecrated not to God, but the Devil.

[6] Jill Tan Radovan of Interaksyon.com writes, "Seklusyon succeeds at being the ‘real horror movie’ that its creators—Reality Entertainment and Eric Matti [sic]—intended it to be [...] Taken literally, it sends goosebumps up one’s spine.

"[8] Clarence Tsui for The Hollywood Reporter writes, “Seclusion drips with a ferocity about how false messiahs manipulate meek minds who, as the film's finale suggests, then propel even more malicious pretenders onto the pedestals of power.

While praising the film as being "immensely intriguing" and "curiously elegant", he feels that the screenplay is awkwardly paced and Ronnie Alonte's performance was wanting.