Selenophene is an organic compound with the chemical formula C4H4Se.

Atoms in selenophene are numbered sequentially around the ring, starting with the selenium atom as number 1 following normal systematic nomenclature rules.

By treating selenium with acetylene and at about 300 °C yields up to 15% selenophene were obtained.

[3] Substituted selenophenes can be made using a Fiesselman procedure in which a β-chloro-aldehyde reacts with sodium selenide, and then ethyl bromoacetate.

As for thiophene, electrophiles tend to attack at the carbon positions next to the chalcogen.