There is no known characterization of self-complementary graphs.
[1] For example, the 3 × 3 rook's graph (the Paley graph of order nine) is self-complementary, by a symmetry that keeps the center vertex in place but exchanges the roles of the four side midpoints and four corners of the grid.
[4] An n-vertex self-complementary graph has exactly half as many edges of the complete graph, i.e., n(n − 1)/4 edges, and (if there is more than one vertex) it must have diameter either 2 or 3.
[1] Since n(n − 1) must be divisible by 4, n must be congruent to 0 or 1 modulo 4; for instance, a 6-vertex graph cannot be self-complementary.
The problems of checking whether two self-complementary graphs are isomorphic and of checking whether a given graph is self-complementary are polynomial-time equivalent to the general graph isomorphism problem.