[5] From the age of 16, Semane assisted Young in the instruction of music and needlework, and by the time she completed her teacher training she was able to teach all the courses offered at the school.

[5] Though a commoner, and not approved of by many BaNgwato because of her status, Semane was selected by Bessie Ratshosa to marry her father Khama III.

Ratshosa picked Semane because of her commitment to Christianity and teaching, believing that she would be a modern role model for BaNgwato women.

[8] Semane and Khama III, as Christians, promoted their faith to the BaNgwato and attempted to outlaw consumption of liquor.

When Sekgoma took ill, she became his nurse, though that created further conflict, as his sisters favored treatment by Tswana healers, rather than European physicians.

[10][12] In 1930, she formed a branch of the Woman's Christian Temperance Union known as the Women's Regiment of Beer and encouraged her son in his efforts to ban alcohol.