The Semowane River is a major natural watercourse in Southern Africa.

Within Botswana the Semowane River forms a boundary between several governmental jurisdictions.

[1] This river is a vital source of water to the ephemeral wetlands of the Makgadikgadi, where a number of species of limited distribution thrive.

[2] Specifically the Semowane River discharges to Sua Pan.

This article related to a river in Botswana is a stub.