Also located in Senatobia is the Baddour Center, a residential care facility for intellectually disabled adults.

On April 13, 1834, early settler James Peters purchased two sections of land from the Chickasaw Nation for the sum of $1.25 per acre.

[6] Two nearby settlements, Tatumsville and Tatesville were both abandoned, with those populations moving to Senatobia in favor of easier transportation.

During the Civil War, the town's business section was burned twice by Federal troops.

As of the 2020 United States Census, there were 8,354 people, 2,470 households, and 1,639 families residing in the city.

26.6% of all households were made up of individuals, and 12.5% had someone living alone who was 65 years of age or older.