However, the school ultimately opened in September 2003 with 860 students from Shamong, Southampton, Tabernacle, and Woodland Townships.

[16] The Seneca High School Golden Eagles[2] participate in the Olympic Conference (New Jersey), which is comprised of public and private high schools in Burlington and Camden counties and operates under the auspices of the New Jersey State Interscholastic Athletic Association (NJSIAA).

[10] The boys' track team, coached by Rich Watson, a physics teacher at Seneca, has enjoyed success with standouts such as the 2006 shuttle hurdle team and record-setting performances by Drew Kanz-Oshea in the High Jump: 7'1 (2009), and Michael Maira in the Pole Vault: 15'0" (2008-2010).

The 2006 football team reached the South Jersey Group III final but lost to Lacey Township High School 12–0.

[citation needed] The 2006 girls' tennis team won the South Jersey Group III state sectional championship with a pair of 5-0 wins, defeating Ocean City High School in the semifinals and Shawnee High School in the finals.

[26] The team again won the Group III state championship in 2011, defeating Paramus High School by a score of 12–3 in the tournament final.

[29] The 2014 and 2015 boys' lacrosse teams advanced to the South Jersey Group II state championship games.

[31] In 2016, Joe Manchio became the school's first individual state champion in wrestling at Boardwalk Hall in Atlantic City.

[32] The field hockey team won the Central Jersey Group II state sectional championship from 2017 to 2019.