Originally anchored by John Susi and Ali Sotto, it premiered on April 12, 2004, on the network's evening line up replacing Balitang Balita.

It was first anchored by John Susi who was held over from its predecessor Balitang Balita and former actress Ali Sotto.

Sotto that time was in contract with GMA Network under its radio arm DZBB.

Susi and Sotto were later replaced by Martin Andanar, who became the final anchor of the newscast.

On June 25, 2007, Sentro was reformatted into an all-English newscast, as an answer to QTV's News on Q, despite the retention of the name and some of the opening text and ending reminders still in Filipino.