The Sepon River belongs to the Hướng Hóa district of Vietnam and Savannakhet Province of Laos.
Therefore, it is a main artery for the two nearby urban areas (the town of Lao Bảo and the city of Savannakhet).
The river enables cross-border trade and commerce between Lao Bảo and Savannakhet.
The Sepon is also regarded as a minor trade artery linking Vietnam and Thailand.
In addition, one can cross into Laos from Vietnam by motorboat, which takes about 30 minutes to arrive at Savannakhet.