Seppeltsfield, one of Australia's oldest wineries[citation needed], was founded in 1851 by Joseph Ernst Seppelt.

[5] Joseph Ernest Seppelt, a merchant who sold such commodities as tobacco, snuff and liqueurs, emigrated with his family from Prussia to Australia in 1849 to break free from political and economic unrest.

Soon thereafter, the Seppelts planted vines that flourished leading to a contribution to the Wines and Spirits category at the Melbourne Intercolonial Exhibition in 1866.

"Invalid port" and "Hospital brandy" were choice quality wines sold in small quantities and frequently prescribed by doctors in the 19th and early 20th centuries.

The latter was a port wine containing extract of beef, kola nut and coca leaf, produced by Deans, Logan & Co. of Belfast, Ireland, and marketed by Seppelts from around 1908.

[16] The company (and winery) remained in the Seppelt family until 1984 when it became the subject of a share market struggle for its control, and subsequent takeover by SA Brewing Holdings in 1985.

[19] In 2007, ownership of the winery changed again when the Seppeltsfield Estate Trust, (Nathan Waks (managing director) and Bruce Baudinet (chairman), who were also behind the Clare Valley winery, Kilikanoon),[20] purchased Seppelts from the Foster's Group, and started using the Seppeltsfield name on wine labels.

[22] In 2013, the arts and crafts organisation, JamFactory, opened its regional extension on the Seppeltsfield estate, including studios, gallery and shop.

The shop sells an extensive range of hand-crafted ceramics, furniture, glassware, jewellery and other items.