It empties into the Tennessee River downstream from Chattanooga near the Tennessee-Alabama state line.

State Route 30, which descends Walden's Ridge into the Valley and then climbs the escarpment back onto the plateau, crosses here.

Just north of Dunlap, US 127 turns southeastward, beginning the ascent onto Walden Ridge and eventually down into Chattanooga.

A set of railroad tracks previously ran along the river from this point, testament to heavy underground coal extraction in years past.

Shortly south of the Interstate 24 bridge is the mouth of the Sequatchie into the Guntersville Lake impoundment of the Tennessee River.