It is home to part of the world-famous Serengeti National Park a UNESCO World Heritage Site and contains one of the western gates to the park.

[1] According to the 2022 Tanzania National Census, the population of Serengeti District was 340,349.

[2][3] There are no paved roads connecting Serengeti District with the rest of the country.

The unpaved trunk road T17 from Musoma to Arusha passes through the district from west to east.

[4] As of 2012, Serengeti District was administratively divided into 28 wards.