Sergnano (Cremasco: Sergnà) is a comune (municipality) in the Province of Cremona in the Italian region of Lombardy, it is located about 40 kilometres (25 mi) east of Milan and about 40 kilometres (25 mi) northwest of Cremona.

Sergnano borders the following municipalities: Campagnola Cremasca, Capralba, Caravaggio, Casale Cremasco-Vidolasco, Castel Gabbiano, Mozzanica, Pianengo, Ricengo.

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