Spinadesco (Cremunés: Spinadésch) is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about 70 kilometres (43 mi) southeast of Milan and about 8 kilometres (5 mi) west of Cremona.

Spinadesco borders the following municipalities: Acquanegra Cremonese, Castelvetro Piacentino, Cremona, Crotta d'Adda, Monticelli d'Ongina, Sesto ed Uniti.

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