Vaiano Cremasco (Cremish: Vaià) is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about 35 kilometres (22 mi) southeast of Milan and about 45 kilometres (28 mi) northwest of Cremona.

Vaiano Cremasco borders the following municipalities: Bagnolo Cremasco, Crespiatica, Monte Cremasco, Palazzo Pignano, Trescore Cremasco.

Vaiano Cremasco is twinned with:

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