Monoamine neurotoxin

[1] In the case of serotonergic neurotoxins like MDMA, research suggests that simultaneous induction of serotonin and dopamine release, serotonin depletion, dopamine uptake and metabolism, hyperthermia, oxidative stress and antioxidant depletion, and/or drug metabolites may all be involved in the neurotoxicity.

[3][4] On the other hand, there is evidence that drug metabolites may not be involved.

[3][4] Some research suggests that serotonergic neurotoxicity might represent neuroadaptive mechanisms rather than neuronal damage per se.

[5][6] Dopaminergic neurotoxins can induce a Parkinson's disease-like condition in animals and humans.

[1][7] Serotonergic neurotoxins have been associated with cognitive and memory deficits and psychiatric changes.